Human organoids for Risk Group 4 virus research: a new frontier in investigating Nipah virus infection of the central nervous system

ABSTRACT New approach methodologies, such as high-complexity in vitro systems, are increasingly prioritized in biomedical research as potential alternatives to animal experimentation. We show that cerebral organoids derived from human induced pluripotent stem cells can be leveraged to (i) investigat...

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Váldodahkkit:	Gabriella Worwa, Shuǐqìng Yú, Amanda M. W. Hischak, Julie P. Tran, Jeremy J. Bearss, John Bernbaum, Daniel B. Woodburn, Bapi Pahar, Jillian Geiger, Louis M. Huzella, Santiago Vidal Freire, Ian Crozier, César Muñoz-Fontela, Gustavo Palacios, Nicole C. Kleinstreuer, Lina Widerspick, Jens H. Kuhn
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	American Society for Microbiology 2025-11-01
Ráidu:	Journal of Virology
Fáttát:	central nervous system infection complex in vitro system human cerebral organoid maximum containment NAMs new approach methodologies
Liŋkkat:	https://journals.asm.org/doi/10.1128/jvi.01070-25
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