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Human organoids for Risk Group 4 virus research: a new frontier in investigating Nipah virus infection of the central nervous system

ABSTRACT New approach methodologies, such as high-complexity in vitro systems, are increasingly prioritized in biomedical research as potential alternatives to animal experimentation. We show that cerebral organoids derived from human induced pluripotent stem cells can be leveraged to (i) investigat...

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Автори: Gabriella Worwa, Shuǐqìng Yú, Amanda M. W. Hischak, Julie P. Tran, Jeremy J. Bearss, John Bernbaum, Daniel B. Woodburn, Bapi Pahar, Jillian Geiger, Louis M. Huzella, Santiago Vidal Freire, Ian Crozier, César Muñoz-Fontela, Gustavo Palacios, Nicole C. Kleinstreuer, Lina Widerspick, Jens H. Kuhn
Формат: Artigo
Мова:Inglês
Опубліковано: American Society for Microbiology 2025-11-01
Серія:Journal of Virology
Предмети:
central nervous system infection
complex in vitro system
human cerebral organoid
maximum containment
NAMs
new approach methodologies
Онлайн доступ:https://journals.asm.org/doi/10.1128/jvi.01070-25
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