In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi
Geldanamycin (GA) is a benzoquinone-containing ansamycin that inhibits heat shock protein 90. GA derivatives are being evaluated as anti-neoplastic agents, but their utility against parasites whose heat shock proteins (Hsps) have homology with human Hsp90 is unknown. The activities of four syntheti...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Wiley
2010-01-01
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| Schriftenreihe: | Journal of Parasitology Research |
| Online-Zugang: | http://dx.doi.org/10.1155/2010/716498 |
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