Paromomycin targets HDAC1-mediated SUMOylation and IGF1R translocation in glioblastoma

ObjectiveThis study investigates the effects of Paromomycin on SUMOylation-related pathways in glioblastoma (GBM), specifically targeting HDAC1 inhibition.MethodsUsing TCGA and GTEx datasets, we identified SUMOylation-related genes associated with GBM prognosis. Molecular docking analysis suggested...

Deskribapen osoa

Xehetasun bibliografikoak

Egile Nagusiak:	Zhong Min, Yuejie Guo, Luo Ning
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2024-12-01
Saila:	Frontiers in Pharmacology
Gaiak:	glioblastoma multiforme Paromomycin HDAC1 SUMOylation IGF1R drug screening
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1490878/full
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!