Paromomycin targets HDAC1-mediated SUMOylation and IGF1R translocation in glioblastoma

ObjectiveThis study investigates the effects of Paromomycin on SUMOylation-related pathways in glioblastoma (GBM), specifically targeting HDAC1 inhibition.MethodsUsing TCGA and GTEx datasets, we identified SUMOylation-related genes associated with GBM prognosis. Molecular docking analysis suggested...

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Bibliografske podrobnosti

Principais autores:	Zhong Min, Yuejie Guo, Luo Ning
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2024-12-01
Serija:	Frontiers in Pharmacology
Teme:	glioblastoma multiforme Paromomycin HDAC1 SUMOylation IGF1R drug screening
Online dostop:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1490878/full
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