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Enhanced amphiregulin exposure promotes modulation of the high grade serous ovarian cancer tumor immune microenvironment

High grade serous ovarian cancer (HGSOC) is a lethal gynecologic malignancy in which chemoresistant recurrence rates remain high. Furthermore, HGSOC patients have demonstrated overall low response rates to clinically available immunotherapies. Amphiregulin (AREG), a low affinity epidermal growth fac...

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Principais autores: Jasmine Ebott, Julia McAdams, Chloe Kim, Corrine Jansen, Morgan Woodman, Payton De La Cruz, Christoph Schrol, Jennifer Ribeiro, Nicole James
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-05-01
coleção:Frontiers in Pharmacology
Assuntos:
amphiregulin (AREG)
high-grade serous ovarian cancer
tumor immune microenvioronment
immunosupperssion
chemoresistance
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2024.1375421/full
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