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Novel 4-alkoxy Meriolin Congeners Potently Induce Apoptosis in Leukemia and Lymphoma Cells

<i>Meriolins</i> (3-(pyrimidin-4-yl)-7-azaindoles) are synthetic hybrids of the naturally occurring alkaloids <i>variolin</i> and <i>meridianin</i> and display a strong cytotoxic potential. We have recently shown that the novel derivative <i>meriolin</i> <b>16</b> is highly cytotoxic in several lymp...

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Autori principali: Karina S. Krings, Tobias R. Wassenberg, Pablo Cea-Medina, Laura Schmitt, Ilka Lechtenberg, Tanya R. Llewellyn, Nan Qin, Holger Gohlke, Sebastian Wesselborg, Thomas J. J. Müller
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2024-12-01
Serie:Molecules
Soggetti:
apoptosis inducers
7-azaindoles
biheteroaryls
cyclin dependent kinases (CDK)
leukemia cell lines
lymphoma cell lines
Accesso online:https://www.mdpi.com/1420-3049/29/24/6050
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