Leveraging in vitro and pharmacokinetic models to support bench to bedside investigation of XTMAB-16 as a novel pulmonary sarcoidosis treatment

Background: Sarcoidosis is a chronic, multisystem inflammatory disorder characterized by non-caseating epithelioid granulomas; infiltration of mononuclear cells; and destruction of microarchitecture in the skin, eye, heart, and central nervous system, and the lung in >90% of cases. XTMAB-16 is a...

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Autors principals:	Elliot Offman, Noopur Singh, Mark W. Julian, Landon W. Locke, Sabahattin Bicer, Jonah Mitchell, Thomas Matthews, Kirsten Anderson, Elliott D. Crouser
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-03-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	sarcoidosis XTMAB-16 TNFα granuloma population pharmacokinetic modeling
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1066454/full
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