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Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

ABSTRACT Sarcoidosis is a systemic granulomatous disease that has limited treatment options. Emerging evidence suggests that macrophages are essential for sarcoid granuloma initiation. Legumain (LGMN), a cysteine protease, regulates macrophage polarization in various cancers. However, its involvemen...

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Principais autores: Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-06-01
Serier:Advanced Science
Fag:
granulomas
legumain
lipid nanoparticles
macrophages
sarcoidosis
Online adgang:https://doi.org/10.1002/advs.202520635
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