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Single-cell RNA sequencing reveals disease associated changes in brain endothelial cells in the 5XFAD mouse

Abstract Vascular dysfunction is a key contributor to Alzheimer’s disease (AD) pathology, where changes to the endothelium and its crucial role in maintaining blood-brain barrier (BBB) integrity have been of particular emphasis. The transgenic 5XFAD (5X Familial Alzheimer’s Disease) mouse model, whi...

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Xehetasun bibliografikoak
Egile Nagusiak: Rebecca J. Embalabala, Haley Masters, Elaina Ziehm, Jamie Pouncey, Hyosung Kim, Ethan S. Lippmann
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BMC 2026-01-01
Saila:Fluids and Barriers of the CNS
Gaiak:
Sarrera elektronikoa:https://doi.org/10.1186/s12987-026-00766-w
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