A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging

A hallmark of aging is loss of differentiated cell identity. Aged Drosophila midgut differentiated enterocytes (ECs) lose their identity, impairing tissue homeostasis. To discover identity regulators, we performed an RNAi screen targeting ubiquitin-related genes in ECs. Seventeen genes were identifi...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Neta Erez, Lena Israitel, Eliya Bitman-Lotan, Wing H Wong, Gal Raz, Dayanne V Cornelio-Parra, Salwa Danial, Na'ama Flint Brodsly, Elena Belova, Oksana Maksimenko, Pavel Georgiev, Todd Druley, Ryan D Mohan, Amir Orian
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2021-02-01
coleção:	eLife
Assuntos:	aging cell identity gut gene regulation ubiquitin USP22/ Non-stop
Acesso em linha:	https://elifesciences.org/articles/62312
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!