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The transcription factor Hey and nuclear lamins specify and maintain cell identity

The inability of differentiated cells to maintain their identity is a hallmark of age-related diseases. We found that the transcription factor Hey supervises the identity of differentiated enterocytes (ECs) in the adult Drosophila midgut. Lineage tracing established that Hey-deficient ECs are unable...

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Principais autores: Naama Flint Brodsly, Eliya Bitman-Lotan, Olga Boico, Adi Shafat, Maria Monastirioti, Manfred Gessler, Christos Delidakis, Hector Rincon-Arano, Amir Orian
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2019-07-01
coleção:eLife
Assuntos:
cell identity
gene regulation
nuclear organization
hey
lamin
ageing
Acesso em linha:https://elifesciences.org/articles/44745
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