Measuring growth, resistance, and recovery after artemisinin treatment of Plasmodium falciparum in a single semi-high-throughput assay

Abstract Background Artemisinin partial resistance (ART-R) has spread throughout Southeast Asia and mutations in Pfkelch13, the molecular marker of resistance, are widely reported in East Africa. Effective in vitro assays and robust phenotypes are crucial for monitoring populations for the emergence...

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Principais autores:	Mackenzie A. C. Sievert, Tarrick Qahash, Puspendra P. Singh, Douglas A. Shoue, Lisa A. Checkley, Katelyn Vendrely Brenneman, Zione Cassady, Sudhir Kumar, Xue Li, François H. Nosten, Timothy J. C. Anderson, Ashley M. Vaughan, Jeanne Romero-Severson, Michael T. Ferdig
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-08-01
coleção:	Malaria Journal
Assuntos:	Ring-stage survival assay Artemisinin resistance Plasmodium falciparum Kelch13 Phenotypes Genetic cross
Acesso em linha:	https://doi.org/10.1186/s12936-025-05481-9
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