MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response

The type I interferon system is essential for antiviral immune response and is a primary target of viral immune evasion strategies. Here, we show that virus infection induces the expression of MAPK phosphatase 5 (MKP5), a dual-specificity phosphatase (DUSP), in host cells. Mice deficient in MKP5 wer...

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Detalhes bibliográficos

Principais autores:	Sharmy J. James, Huipeng Jiao, Hong-Ying Teh, Hirotaka Takahashi, Chin Wen Png, Meng Chee Phoon, Youichi Suzuki, Tatsuy Sawasaki, Hui Xiao, Vincent T.K. Chow, Naoki Yamamoto, Joseph M. Reynolds, Richard A. Flavell, Chen Dong, Yongliang Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2015-03-01
Colecção:	Cell Reports
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S221112471500176X
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