Constitutive gene expression in monocytes from chronic HIV-1 infection overlaps with acute Toll-like receptor induced monocyte activation profiles.

Elevated TLR expression/signalling in monocyte/macrophages has been shown to mediate systemic immune activation, a hallmark of progressive HIV-1 infection. Here we show, via differential gene expression comparisons, the presence of a constitutive in vivo TLR-like gene activation signature in steady-...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Bethsebah Gekonge, Malavika S Giri, Andrew V Kossenkov, Michael Nebozyhn, Malik Yousef, Karam Mounzer, Louise Showe, Luis J Montaner
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2012-01-01
Serija:	PLoS ONE
Online dostop:	http://europepmc.org/articles/PMC3399809?pdf=render
Oznake:	Označite Brez oznak, prvi označite!