Constitutive gene expression in monocytes from chronic HIV-1 infection overlaps with acute Toll-like receptor induced monocyte activation profiles.

Elevated TLR expression/signalling in monocyte/macrophages has been shown to mediate systemic immune activation, a hallmark of progressive HIV-1 infection. Here we show, via differential gene expression comparisons, the presence of a constitutive in vivo TLR-like gene activation signature in steady-...

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Principais autores:	Bethsebah Gekonge, Malavika S Giri, Andrew V Kossenkov, Michael Nebozyhn, Malik Yousef, Karam Mounzer, Louise Showe, Luis J Montaner
格式:	Artigo
語言:	Inglês
出版:	Public Library of Science (PLoS) 2012-01-01
叢編:	PLoS ONE
在線閱讀:	http://europepmc.org/articles/PMC3399809?pdf=render
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