Improving the production of 22-hydroxy-23,24-bisnorchol-4-ene-3-one from sterols in Mycobacterium neoaurum by increasing cell permeability and modifying multiple genes

Abstract Background The strategy of modifying the sterol catabolism pathway in mycobacteria has been adopted to produce steroidal pharmaceutical intermediates, such as 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC), which is used to synthesize various steroids in the industry. However, the producti...

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Detalhes bibliográficos

Principais autores:	Liang-Bin Xiong, Hao-Hao Liu, Li-Qin Xu, Wan-Ju Sun, Feng-Qing Wang, Dong-Zhi Wei
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-05-01
coleção:	Microbial Cell Factories
Assuntos:	Mycobacterium 22-Hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC) mmpL3 choM cyp125 fadA5
Acesso em linha:	http://link.springer.com/article/10.1186/s12934-017-0705-x
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