Identification, function, and application of 3-ketosteroid Δ1-dehydrogenase isozymes in Mycobacterium neoaurum DSM 1381 for the production of steroidic synthons

Abstract Background 3-Ketosteroid-Δ1-dehydrogenase (KstD) is a key enzyme in the metabolic pathway for chemical modifications of steroid hormones. Only a few KstDs have thus far been characterized biochemically and applied for the production of steroidal pharmaceutical intermediates. Three KstDs, Ks...

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Principais autores:	Ruijie Zhang, Xiangcen Liu, Yushi Wang, Yuchang Han, Junsong Sun, Jiping Shi, Baoguo Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-05-01
coleção:	Microbial Cell Factories
Assuntos:	Mycobacterium 3-Ketosteroid-∆1-dehydrogenase 22-Hydroxy-23,24-bisnorchol-4-ene-3-one (4HP) 1,4-Androstadiene-3,17-dione (ADD) steroids
Acesso em linha:	http://link.springer.com/article/10.1186/s12934-018-0916-9
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