Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted

Abstract Many archetypal and emerging classes of small-molecule therapeutics form covalent protein adducts. In vivo, both the resulting conjugates and their off-target side-conjugates have the potential to elicit antibodies, with implications for allergy and drug sequestration. Although β-lactam ant...

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Autores principales:	Lachlan P. Deimel, Lucile Moynié, Guoxuan Sun, Viliyana Lewis, Abigail Turner, Charles J. Buchanan, Sean A. Burnap, Mikhail Kutuzov, Carolin M. Kobras, Yana Demyanenko, Shabaz Mohammed, Mathew Stracy, Weston B. Struwe, Andrew J. Baldwin, James Naismith, Benjamin G. Davis, Quentin J. Sattentau
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2024-08-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-024-51138-7
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