Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted

Abstract Many archetypal and emerging classes of small-molecule therapeutics form covalent protein adducts. In vivo, both the resulting conjugates and their off-target side-conjugates have the potential to elicit antibodies, with implications for allergy and drug sequestration. Although β-lactam ant...

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मुख्य लेखकों:	Lachlan P. Deimel, Lucile Moynié, Guoxuan Sun, Viliyana Lewis, Abigail Turner, Charles J. Buchanan, Sean A. Burnap, Mikhail Kutuzov, Carolin M. Kobras, Yana Demyanenko, Shabaz Mohammed, Mathew Stracy, Weston B. Struwe, Andrew J. Baldwin, James Naismith, Benjamin G. Davis, Quentin J. Sattentau
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Nature Portfolio 2024-08-01
श्रृंखला:	Nature Communications
ऑनलाइन पहुंच:	https://doi.org/10.1038/s41467-024-51138-7
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