Characterization of pyruvate metabolism and citric acid cycle patterns predicts response to immunotherapeutic and ferroptosis in gastric cancer

Abstract Background Gastric cancer is one of the most common malignancies of the digestive system with a high lethal rate. Studies have shown that inherited and acquired mutations in pyruvate metabolism and citric acid cycle (P-CA) enzymes are involved in tumorigenesis and tumor development. However...

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Detalhes bibliográficos

Principais autores:	Xu Wang, Bing Xu, Jing Du, Jun Xia, Guojie Lei, Chaoting Zhou, Jiayu Hu, Yinhao Zhang, Sufeng Chen, Fangchun Shao, Jiyun Yang, Yanchun Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-10-01
coleção:	Cancer Cell International
Assuntos:	Gastric cancer Pyruvate metabolism Citric acid cycle Tumor microenvironment Tumor mutational burden Immunotherapy
Acesso em linha:	https://doi.org/10.1186/s12935-022-02739-z
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