USP4-Mediated deubiquitination of A2AR suppresses autophagy-dependent ferroptosis in gastric cancer
Abstract Deubiquitinating enzymes (DUBs) are crucial for regulating the degradation of specific proteins and represent a novel therapeutic direction in cancer. In gastric cancer, USP4 levels are significantly elevated, though its therapeutic potential remains underexplored. Our study demonstrates th...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Springer
2025-10-01
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| Col·lecció: | Cellular and Molecular Life Sciences |
| Matèries: | |
| Accés en línia: | https://doi.org/10.1007/s00018-025-05826-2 |
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