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USP4-Mediated deubiquitination of A2AR suppresses autophagy-dependent ferroptosis in gastric cancer

Abstract Deubiquitinating enzymes (DUBs) are crucial for regulating the degradation of specific proteins and represent a novel therapeutic direction in cancer. In gastric cancer, USP4 levels are significantly elevated, though its therapeutic potential remains underexplored. Our study demonstrates th...

Бүрэн тодорхойлолт

-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Xuan Zhao, Sheng Lu, Zhaoyu Xiang, Min Yan, Zheng-Gang Zhu, Feng Dong, Chao Yan
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: Springer 2025-10-01
Цуврал:Cellular and Molecular Life Sciences
Нөхцлүүд:
Онлайн хандалт:https://doi.org/10.1007/s00018-025-05826-2
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