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Aging-related alternative splicing drive neoantigen emergence revealed by transcriptome analysis of 1,255 human blood samples

This study aimed to identify age-related genes and alternative splicing (AS) events by comprehensive transcriptome analysis of 1,255 healthy blood samples from individuals aged 8–87 years. We identified 1,029 up-regulated and 1,186 down-regulated genes in older individuals, including 17 genes overla...

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Principais autores: Shuhan Li, Haohao Lv, Renxin Zhang, Jinjun Li, Zhiyuan Chen, Naixue Yang, Shaoxing Dai
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-05-01
coleção:Frontiers in Aging
Assuntos:
aging
transcriptome analysis
alternative splicing
immunosenescence
neoantigens
anti-aging immunotherapy
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fragi.2025.1575862/full
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