TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro

Abstract Background There is a lack of effective therapeutic strategies for amyotrophic lateral sclerosis (ALS); therefore, drug repurposing might provide a rapid approach to meet the urgent need for treatment. Methods To identify therapeutic targets associated with ALS, we conducted Mendelian rando...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Qing-Qing Duan, Han Wang, Wei-Ming Su, Xiao-Jing Gu, Xiao-Fei Shen, Zheng Jiang, Yan-Ling Ren, Bei Cao, Guo-Bo Li, Yi Wang, Yong-Ping Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-03-01
Edice:	BMC Medicine
Témata:	Amyotrophic lateral sclerosis Mendelian randomization Drug repurposing Druggable gene TBK1
On-line přístup:	https://doi.org/10.1186/s12916-024-03314-1
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!