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TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro

Abstract Background There is a lack of effective therapeutic strategies for amyotrophic lateral sclerosis (ALS); therefore, drug repurposing might provide a rapid approach to meet the urgent need for treatment. Methods To identify therapeutic targets associated with ALS, we conducted Mendelian rando...

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Principais autores: Qing-Qing Duan, Han Wang, Wei-Ming Su, Xiao-Jing Gu, Xiao-Fei Shen, Zheng Jiang, Yan-Ling Ren, Bei Cao, Guo-Bo Li, Yi Wang, Yong-Ping Chen
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-03-01
Serier:BMC Medicine
Fag:
Amyotrophic lateral sclerosis
Mendelian randomization
Drug repurposing
Druggable gene
TBK1
Online adgang:https://doi.org/10.1186/s12916-024-03314-1
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