cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma

Bone marrow-derived mesenchymal stem cells (BMSCs) are proposed as the cells of origin of several subtypes of osteosarcoma (OS). However, signals that direct BMSCs to form different subtypes of OS are unclear. Here we show that the default tumor type from spontaneously transformed p53 knockout (p53_...

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Detalhes bibliográficos

Principais autores:	Yunlong He, Wentao Zhu, Min Hwa Shin, Joy Gary, Chengyu Liu, Wendy Dubois, Shelley B. Hoover, Shunlin Jiang, Eryney Marrogi, Beverly Mock, R. Mark Simpson, Jing Huang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2017-06-01
Colecção:	Stem Cell Reports
Assuntos:	mesenchymal stem cells p53 osteosarcoma cFOS SOX9 RAS AKT stem cells cancer cancer stem cells
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213671117301832
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