An HDAC4-specific PROTAC degrader achieves radiation sensitization by enhancing ferroptosis in lung cancer

Abstract Post-translational modifications (PTMs) play a critical role in cancer radioresistance, yet how they regulate ferroptosis to influence radiotherapy response remains poorly understood. Here, we show that HDAC4 promotes radiation resistance in lung cancer by inhibiting ferroptosis. Through a...

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מידע ביבליוגרפי

Principais autores:	Chun Cheng, Longhua Sun, Jiaxue Yang, Zhiliang Liu, Fan Zhang, Lingyan Qiu, Meng Yu, Ting Wang, Jianxin Huang, Li Wang, Wei-Ping Min, Tingxiu Xiang, Kaishun Hu, Yi Sang
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Portfolio 2026-05-01
סדרה:	Nature Communications
גישה מקוונת:	https://doi.org/10.1038/s41467-026-73682-0
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