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Development of highly potent and selective oncogenic KRASG12D PROTAC degraders

As a key driver of tumorigenesis and cancer development, the KRASG12D mutation is ubiquitous existed in KRAS-associated malignancies, highlighting the urgent clinical need for effective KRASG12D targeting drugs. In this study, through rational design and multiple cell type-based antiproliferative ev...

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Principais autores: Yaqiu Mao, Pengli Wei, Ting Wei, Yalei Wang, Zhenze Qi, Xu Cai, Changkai Jia, Zhiyuan Zhao, Bingkun Li, Min Qiao, Yaxin Zou, Zhihui Mu, Xiaofang Lei, Tingting Yang, Shiyang Sun, Xuesong Feng, Pengyun Li, Zhibing Zheng
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-12-01
Serier:European Journal of Medicinal Chemistry Reports
Fag:
KRASG12D
Drug design
Molecular dynamics
PROTAC
Anticancer
Online adgang:http://www.sciencedirect.com/science/article/pii/S2772417425000524
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