Human peritoneal fluid exerts ovulation- and nonovulation-sourced oncogenic activities on transforming fallopian tube epithelial cells

Abstract Secretory cells in the fallopian tube fimbria epithelium (FTE) are regarded as the main cells of origin of ovarian high-grade serous carcinoma (HGSC). Ovulation is the main cause of FTE oncogenesis, which proceeds through a sequence of TP53 mutations, chromosomal instability due to Rb/cycli...

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Autori principali:	Che-Fang Hsu, Vaishnavi Seenan, Liang-Yuan Wang, Pao-Chu Chen, Dah-Ching Ding, Tang-Yuan Chu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-07-01
Serie:	Cancer Cell International
Soggetti:	High-grade serous carcinoma Fallopian tube epithelium Follicular fluid Peritoneal fluid Peritoneal seeding
Accesso online:	https://doi.org/10.1186/s12935-024-03406-1
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