Human peritoneal fluid exerts ovulation- and nonovulation-sourced oncogenic activities on transforming fallopian tube epithelial cells

Abstract Secretory cells in the fallopian tube fimbria epithelium (FTE) are regarded as the main cells of origin of ovarian high-grade serous carcinoma (HGSC). Ovulation is the main cause of FTE oncogenesis, which proceeds through a sequence of TP53 mutations, chromosomal instability due to Rb/cycli...

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Hlavní autoři:	Che-Fang Hsu, Vaishnavi Seenan, Liang-Yuan Wang, Pao-Chu Chen, Dah-Ching Ding, Tang-Yuan Chu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-07-01
Edice:	Cancer Cell International
Témata:	High-grade serous carcinoma Fallopian tube epithelium Follicular fluid Peritoneal fluid Peritoneal seeding
On-line přístup:	https://doi.org/10.1186/s12935-024-03406-1
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