Molecular alterations of isocitrate dehydrogenase 1 and 2 (<it>IDH1 </it>and <it>IDH2</it>) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients

<p>Abstract</p> <p>Background</p> <p>Isocitrate dehydrogenase 1 and 2 (<it>IDH1 </it>and <it>IDH2</it>) metabolic genes encode cytosolic and mitochondrial enzymes that catalyze the conversion of isocitrate to α-ketoglutarate. Acquired somatic mutations of <it>IDH1 </it>and <it>IDH2 </it>have recentl...

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Huvudupphov:	Chotirat Sadudee, Thongnoppakhun Wanna, Promsuwicha Orathai, Boonthimat Chetsada, Auewarakul Chirayu U
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2012-03-01
Serie:	Journal of Hematology & Oncology
Ämnen:	Acute myeloid leukemia Isocitrate dehydrogenase Metabolic enzymes <it>IDH1</it> <it>IDH2</it> Cooperative mutations Normal karyotype
Länkar:	http://www.jhoonline.org/content/5/1/5
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