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DNA methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts

Abstract Background DNA methylation is an important epigenetic modification which has numerous roles in modulating genome function. Its levels are spatially correlated across the genome, typically high in repressed regions but low in transcription factor (TF) binding sites and active regulatory regi...

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Principais autores: Martina Rimoldi, Ning Wang, Jilin Zhang, Diego Villar, Duncan T. Odom, Jussi Taipale, Paul Flicek, Maša Roller
Format: Artigo
Jezik:Inglês
Izdano: BMC 2024-06-01
Serija:Genome Biology
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Online dostop:https://doi.org/10.1186/s13059-024-03218-6
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