DNA methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts

Abstract Background DNA methylation is an important epigenetic modification which has numerous roles in modulating genome function. Its levels are spatially correlated across the genome, typically high in repressed regions but low in transcription factor (TF) binding sites and active regulatory regi...

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Hauptverfasser:	Martina Rimoldi, Ning Wang, Jilin Zhang, Diego Villar, Duncan T. Odom, Jussi Taipale, Paul Flicek, Maša Roller
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-06-01
Schriftenreihe:	Genome Biology
Schlagworte:	DNA methylation Transcription factor binding Evolution Mammals
Online-Zugang:	https://doi.org/10.1186/s13059-024-03218-6
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