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Development of nitroalkene-based inhibitors to target STING-dependent inflammation

Stimulator of Interferon Genes (STING) is essential for the inflammatory response to cytosolic DNA. Despite that aberrant activation of STING is linked to an increasing number of inflammatory diseases, the development of inhibitors has been challenging, with no compounds in the pipeline beyond the p...

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Principais autores: Fei Chang, Camilla Gunderstofte, Nicole Colussi, Mareena Pitts, Sonia R. Salvatore, Anne L. Thielke, Lucia Turell, Beatriz Alvarez, Raphaela Goldbach-Mansky, Luis Villacorta, Christian K. Holm, Francisco J. Schopfer, Anne Louise Hansen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-08-01
coleção:Redox Biology
Assuntos:
Stimulator of Interferon Genes (STING)
Drug discovery
Nitroalkene-based compounds
STING inhibitors
STING-associated vasculopathy with onset in infancy (SAVI)
Interferon
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231724001800
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