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Nasal microbionts differentially colonize and elicit cytokines in human nasal epithelial organoids

ABSTRACT Nasal colonization by Staphylococcus aureus or Streptococcus pneumoniae is associated with an increased risk of infection by these pathobionts, whereas nasal colonization by Dolosigranulum species is associated with health. Human nasal epithelial organoids (HNOs) differentiated at air-liqui...

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Principais autores: Andrea I. Boyd, Leah A. Kafer, Isabel F. Escapa, Amal Kambal, Hira Tariq, Susan G. Hilsenbeck, Hoa Nguyen-Phuc, Anubama Rajan, Joshua M. Lensmire, Kathryn A. Patras, Pedro A. Piedra, Sarah E. Blutt, Katherine P. Lemon
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2025-10-01
Serier:mSphere
Fag:
human nasal organoids
HNO
nasal colonization
epithelial innate immune response
bacterial colonization
Dolosigranulum pigrum
Online adgang:https://journals.asm.org/doi/10.1128/msphere.00493-25
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