Tissue Treg Secretomes and Transcription Factors Shared With Stem Cells Contribute to a Treg Niche to Maintain Treg-Ness With 80% Innate Immune Pathways, and Functions of Immunosuppression and Tissue Repair

We used functional -omics angles and examined transcriptomic heterogeneity in CD4+Foxp3+ regulatory T cells (Treg) from spleen (s-Treg), lymph nodes (LN-Treg), intestine (int-Treg), and visceral adipose tissue (VAT-Treg), and made significant findings: 1) Five new shared Treg genes including NIBAN,...

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Hlavní autoři:	Ruijing Zhang, Keman Xu, Ying Shao, Yu Sun, Jason Saredy, Elizabeth Cutler, Tian Yao, Ming Liu, Lu Liu, Charles Drummer IV, Yifan Lu, Fatma Saaoud, Dong Ni, Jirong Wang, Yafeng Li, Rongshan Li, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-02-01
Edice:	Frontiers in Immunology
Témata:	CD4+Foxp3+ regulatory T cells (Treg) Treg transcription factors (TFs) Treg CD markers Treg secretome stem cell secretomes and TFs
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.632239/full
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