Tissue Treg Secretomes and Transcription Factors Shared With Stem Cells Contribute to a Treg Niche to Maintain Treg-Ness With 80% Innate Immune Pathways, and Functions of Immunosuppression and Tissue Repair

We used functional -omics angles and examined transcriptomic heterogeneity in CD4+Foxp3+ regulatory T cells (Treg) from spleen (s-Treg), lymph nodes (LN-Treg), intestine (int-Treg), and visceral adipose tissue (VAT-Treg), and made significant findings: 1) Five new shared Treg genes including NIBAN,...

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Detalhes bibliográficos

Principais autores:	Ruijing Zhang, Keman Xu, Ying Shao, Yu Sun, Jason Saredy, Elizabeth Cutler, Tian Yao, Ming Liu, Lu Liu, Charles Drummer IV, Yifan Lu, Fatma Saaoud, Dong Ni, Jirong Wang, Yafeng Li, Rongshan Li, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-02-01
coleção:	Frontiers in Immunology
Assuntos:	CD4+Foxp3+ regulatory T cells (Treg) Treg transcription factors (TFs) Treg CD markers Treg secretome stem cell secretomes and TFs
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.632239/full
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