Cancer-associated fibroblasts promote tumor progression in fusion-positive rhabdomyosarcoma

Abstract In children, rhabdomyosarcoma is the most common tumor originating in soft connective tissue. The PAX3/PAX7-FOXO1 fusion-positive alveolar subtype has poor clinical outcomes, with frequent recurrence, metastasis, and low survival. Current therapies may be limited by the tumor microenvironme...

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Autors principals:	Patrick Sipila, Son Tran, Chunfen Zhang, David Douglass, Anne-Marie Langevin, Aru Narendran
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-10-01
Col·lecció:	Scientific Reports
Matèries:	Cancer-associated fibroblast PAX3-FOXO1 Fusion-positive rhabdomyosarcoma Tumor microenvironment Pediatric oncology CXCR4
Accés en línia:	https://doi.org/10.1038/s41598-025-20994-8
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