USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor α

Abstract Although endocrine therapies targeting estrogen receptor α (ERα) are effective in managing ER positive (+) breast cancer, many patients have primary resistance or develop resistance to endocrine therapies. In addition, ER+ breast cancer with PIK3CA activating mutations and 11q13-14 amplific...

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Principais autores:	Jiawei Cao, Du Wu, Guang Wu, Yaqi Wang, Tianhao Ren, Yang Wang, Yingshuai Lv, Wei Sun, Jieyi Wang, Changrui Qian, Licai He, Kaiyan Yang, Hongzhi Li, Haihua Gu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2021-06-01
Series:	Cell Death and Disease
Acceso en liña:	https://doi.org/10.1038/s41419-021-03904-4
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