Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity

Abstract Background Cyclin-dependent kinase 5 (Cdk5) belongs to the family of proline-directed serine/threonine kinases and plays a critical role in neuronal differentiation, migration, synaptogenesis, plasticity, neurotransmission and apoptosis. The deregulation of Cdk5 activity was observed in pos...

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Detalhes bibliográficos

Principais autores:	Anna Wilkaniec, Magdalena Gąssowska-Dobrowolska, Marcin Strawski, Agata Adamczyk, Grzegorz A. Czapski
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-01-01
coleção:	Journal of Neuroinflammation
Assuntos:	Neuroinflammation Amyloid beta Alzheimer’s disease Cdk5 Cytokines Gene expression
Acesso em linha:	http://link.springer.com/article/10.1186/s12974-017-1027-y
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