The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance

Increased oxidative stress, dysfunctional cellular clearance, and chronic inflammation are associated with age-related macular degeneration (AMD). Prolyl oligopeptidase (PREP) is a serine protease that has numerous cellular functions, including the regulation of oxidative stress, protein aggregation...

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Autors principals:	Maija Toppila, Maria Hytti, Eveliina Korhonen, Sofia Ranta-aho, Niina Harju, Markus M. Forsberg, Kai Kaarniranta, Aaro Jalkanen, Anu Kauppinen
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2023-06-01
Col·lecció:	Antioxidants
Matèries:	prolyl oligopeptidase inhibitor retinal pigment epithelium age-related macular degeneration proteasomal dysfunction ROS inflammation
Accés en línia:	https://www.mdpi.com/2076-3921/12/6/1279
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