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The Prolyl Oligopeptidase Inhibitor KYP-2047 Is Cytoprotective and Anti-Inflammatory in Human Retinal Pigment Epithelial Cells with Defective Proteasomal Clearance

Increased oxidative stress, dysfunctional cellular clearance, and chronic inflammation are associated with age-related macular degeneration (AMD). Prolyl oligopeptidase (PREP) is a serine protease that has numerous cellular functions, including the regulation of oxidative stress, protein aggregation...

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Principais autores: Maija Toppila, Maria Hytti, Eveliina Korhonen, Sofia Ranta-aho, Niina Harju, Markus M. Forsberg, Kai Kaarniranta, Aaro Jalkanen, Anu Kauppinen
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-06-01
coleção:Antioxidants
Assuntos:
prolyl oligopeptidase inhibitor
retinal pigment epithelium
age-related macular degeneration
proteasomal dysfunction
ROS
inflammation
Acesso em linha:https://www.mdpi.com/2076-3921/12/6/1279
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