Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity
5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0.3% of the pop...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
University of São Paulo
2018-12-01
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| coleção: | Autopsy and Case Reports |
| Assuntos: | |
| Acesso em linha: | http://www.revistas.usp.br/autopsy/article/view/152614 |
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