Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity

5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0.3% of the pop...

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Bibliografiske detaljer

Principais autores:	Shiraz S. Fidai, Aarti E. Sharma, Daniel N. Johnson, Jeremy P. Segal, Ricardo R. Lastra
Format:	Artigo
Sprog:	Inglês
Udgivet:	University of São Paulo 2018-12-01
Serier:	Autopsy and Case Reports
Fag:	Dihydropyrimidine Dehydrogenase Deficiency Drug-Related Side Effects and Adverse Reactions Genetic Testing; Fluorouracil Pancytopenia
Online adgang:	http://www.revistas.usp.br/autopsy/article/view/152614
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