Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells

The pathogenesis of Huntington’s disease (HD), an inherited progressive neurodegenerative disease, is highly associated with the cytotoxicity-inducing mutant huntingtin (mHtt) protein. Emerging evidence indicates that autophagy plays a pivotal role in degrading aggregated proteins such as mHtt to en...

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主要な著者:	Yueshan Sun, Xueqin Jiang, Rong Pan, Xiaogang Zhou, Dalian Qin, Rui Xiong, Yiling Wang, Wenqiao Qiu, Anguo Wu, Jianming Wu
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2020-02-01
シリーズ:	Frontiers in Pharmacology
主題:	Huntington’s disease autophagy mHtt Aesculus chinensis Bge. HT22 cells
オンライン･アクセス:	https://www.frontiersin.org/article/10.3389/fphar.2020.00116/full
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