Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells

The pathogenesis of Huntington’s disease (HD), an inherited progressive neurodegenerative disease, is highly associated with the cytotoxicity-inducing mutant huntingtin (mHtt) protein. Emerging evidence indicates that autophagy plays a pivotal role in degrading aggregated proteins such as mHtt to en...

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Hlavní autoři:	Yueshan Sun, Xueqin Jiang, Rong Pan, Xiaogang Zhou, Dalian Qin, Rui Xiong, Yiling Wang, Wenqiao Qiu, Anguo Wu, Jianming Wu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2020-02-01
Edice:	Frontiers in Pharmacology
Témata:	Huntington’s disease autophagy mHtt Aesculus chinensis Bge. HT22 cells
On-line přístup:	https://www.frontiersin.org/article/10.3389/fphar.2020.00116/full
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