RskA Is a Dual Function Activator-Inhibitor That Controls SigK Activity Across Distinct Bacterial Genera

It has been previously shown that RskA, the anti-Sigma factor K of Mycobacterium tuberculosis, inhibits SigK and that mutations in RskA promote high expression of the SigK regulon. The latter observation led us to hypothesize that RskA mutations lead to loss of the anti-Sigma factor function. In thi...

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Bibliografische Detailangaben

Hauptverfasser:	Frédéric J. Veyrier, Cecilia Nieves, Louise H. Lefrancois, Hana Trigui, Antony T. Vincent, Marcel A. Behr
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2020-09-01
Schriftenreihe:	Frontiers in Microbiology
Schlagworte:	M. tuberculosis M. bovis M. orygis Yersinia Sigma factor K anti-Sigma factor
Online-Zugang:	https://www.frontiersin.org/article/10.3389/fmicb.2020.558166/full
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