Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysis

Abstract Background Gastrointestinal stromal tumors (GIST) represent a significant clinical challenge due to their metastatic potential and limited treatment options. Raf kinase inhibitor protein (RKIP), a suppressor of the MAPK signaling pathway, is downregulated in various cancers and acts as a me...

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Autors principals:	Nathália Cristina Campanella, Izabela Natalia Faria Gomes, Ana Laura Vieira Alves, Leticia Ferro Leal, Adriane Feijó Evangelista, Marcela Nunes Rosa, Matias Eliseo Melendez, Viviane Aline Oliveira Silva, Richard Lucas Konichi Dias, Lucas Faria Abrahão-Machado, Iara Santana, Olga Martinho, Denise Peixoto Guimarães, Vitor Marcel Faça, Rui Manuel Reis
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2023-10-01
Col·lecció:	Cancer Cell International
Matèries:	RKIP expression Gene knockout GIST COL3A1 Collagen Cell invasion
Accés en línia:	https://doi.org/10.1186/s12935-023-03102-6
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