Structure-guided loop grafting improves expression and stability of influenza neuraminidase for vaccine development

Influenza virus neuraminidase (NA) is a crucial target for protective antibodies, yet the development of recombinant NA protein as a vaccine has been held back by instability and variable expression. We have taken a pragmatic approach to improving expression and stability of NA by grafting antigenic...

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Autors principals:	Pramila Rijal, Leiyan Wei, Guido C Paesen, David I Stuart, Mark Haworth, Kuan-Ying A Huang, Thomas A Bowden, Alain RM Townsend
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2025-09-01
Col·lecció:	eLife
Matèries:	influenza virus neuraminidase protein expression loop grafting vaccine
Accés en línia:	https://elifesciences.org/articles/105317
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